Delta like ligand4 ameliorates liver fibrogenesis through inhibiting chemokines
HL Weng, Y Liu, Z Shen, J Hu, T Feng, B Dewidar, O Park, HG Augustin, B Gao, Y Li, S Dooley · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Humans have five Notch ligands (Jagged1, Jagged2, Delta like ligand (Dll)1, Dll3 and Dll4) and four receptors (Notch1, 2, 3 and 4). Mutation of Jagged1 or Notch2 causes Alagille syndrome, a disease characterized by defective development of intralobular bile ducts and liver injury but no overt fibrosis. However, the roles of Notch ligands in liver fibrogenesis remain largely unknown. Methods: Immunohistochemical and immunofluorescent staining were used to investigate the potential association between Notch ligands and liver fibrosis in patients with chronic HBV infection. The impact of Notch ligand…
