Loss of gap junctions in biliary atresia occurs simultaneously with declined expression of Protein kinase Cα
JHK Andruszkow, S Groos, C Klaus, U Schneider, C Petersen, N Gassler, R Knüchel, L Luciano · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Biliary atresia (BA) is known as an inflammatory process of the extra hepatic bile ducts, resulting in persistent cholestasis of the newborn. Without surgical intervention and subsequent liver transplantation, progressive cirrhosis leads to death of patients prior to the age of two years. Previous studies detected alterations of gap junctions (GJ) in cholestatic disorders. GJ consist of six connexins (Cx) and form intercellular channels between neighboring cells. By enabling diffusion of ions and small molecules, GJ play a pivotal role e.g. in apoptotic cell death which is known to be a characteristic feature in…
