CareLit Fachartikel
Next generation sequencing analysis of cholestatic patients reveals high impact variation in common and rare candidate genes: Deconstructing the genetic architecture of cholestasis
R Liebe, A Christmann, F Grünhage, C Jüngst, F Lammert · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Dokument
1021477
CareLit-ID
Jahr
2015
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ja
zitierfähig
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Zusammenfassung
Background: Cholestasis indicates bile secretory failure, which might be caused by environmental factors and gene variants, or combination of both. Although there is variability in underlying causes of hepatocellular cholestasis, many patients develop cholestasis of unknown etiology and gene mutations of critical hepatobiliary transporters or their regulators may be suspected. Our aim now was to employ next generation sequencing (NGS) to dissect genetic risk factors in adult patients with cholestatic liver injury of unknown etiology. Methods: The full length coding sequences of 24 genes known to be involved in r…
Schlagworte
Cholestasis
Alkaline Phosphatase
Population
Database
Architecture
Zeitschrift für Gastroenterologie
