Reduced HNF3b (FOXA2) levels in steatosis leads to diminished expression of anti-lipoapoptotic protein ALR

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of hepatic pathologies, ranging from steatosis in its most benign form to cirrhosis in its most advanced form with non-alcoholic steatohepatitis (NASH) in an intermediate level. NASH has been thought to be a liver disease triggered by various factors such as triglyceride accumulation in hepatocytes and followed by oxidant stress and lipid peroxidation causing inflammation and fibrosis. The progression of Steatosis to NASH is facilitated when adaptive mechanisms to protect hepatocytes from fatty acid-mediated lipotoxicity are failing. The winged Hel…