Identification of potential driver genes involved in chromosomal instability and tumor cell migration in hepatocarcinogenesis

Background: The genetic heterogeneity of hepatocellular carcinoma (HCC) limits our understanding of the underlying molecular mechanisms and the development of targeted therapies. In the last years, molecular classification of human HCCs revealed that chromosomal instability (CIN) and the existence of a metastatic signature correlate with a poor patients' prognosis. Based on comprehensive expression profiling data we aim to identify factors involved in the development of a CIN phenotype and tumor cell dissemination in HCC. Methods: Transcriptomic data of 240 primary human HCCs and matched non-neoplastic liver tis…