CareLit Fachartikel
Deficiency of calcium-independent phospholipase A2 beta in vivo causes systematic inflammation and hepatocellular carcinoma
W Wei, J Inhoffen, B Straub, S Tuma, W Stremmel, W Chamulitrat · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Dokument
1021482
CareLit-ID
Jahr
2015
Publikation
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Zusammenfassung
Introduction: Calcium-independent phospholipaseA2beta (iPLA2beta), which is one of the patatin-like phospholipase domain-containing genes, catalyzes the hydrolysis of phospholipids for cell membrane remodeling. It is known that iPLA2beta produces lysophosphatidylcholine as a 'find me signal' for phagocytes to remove apoptotic cells. We hypothesize that deficiency of iPLA2beta leads an accumulation of apoptotic cells, and that the subsequent inflammatory pressure induces the generation of proliferative hepatocytes which further leads to hepatocellular carcinoma (HCC). Methods: Whole body iPLA2beta-/- (with the de…
Schlagworte
Aged
Apoptosis
Calcium
Architecture
Cholangitis
Adenoma
Aging
Actin
Hepatitis
Zeitschrift für Gastroenterologie
