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Human adult liver stem cells generated from patient samples

R Gutierrez Jauregui, N Fekete-Drimusz, MP Manns, FWR Vondran, M Bock · Zeitschrift für Gastroenterologie · 2015 · Heft 01

Dokument
1021483
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
R Gutierrez Jauregui, N Fekete-Drimusz, MP Manns, FWR Vondran, M Bock
Ausgabe
Heft 01 / 2015
Seiten
–
Erschienen: 2015-01-16 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0034-1397174

Zusammenfassung

Background and Aims: Basic and translational research on primary human hepatocytes is currently hindered by the limited availability of functional human hepatocytes. Moreover, once isolated from tissue samples, they rapidly loose their function and do not proliferate when cultured in vitro. This problem could be overcome by using human liver stem cells, propagated in vitro and subsequently differentiated into cells of the different liver cell types, ideally reaching full maturation comparable to native cells in vivo. Methods: Based on the culture of primary hepatocyte cell suspensions obtained from patient resec…

Schlagworte

Liver Cells Human Adult Samples Primary Hepatocytes Tissue Culture These Populations Differentiation Zeitschrift für Gastroenterologie