CareLit Fachartikel
Bispecific antibody constructs mediate immunotherapeutic retargeting of effector cells towards HBV infected target cells
F Bohne, J Hasreiter, O Quitt, V Bruss, G Moldenhauer, F Momburg, U Protzer · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Dokument
1021487
CareLit-ID
Jahr
2015
Publikation
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Retargeting of effector cells is a promising immune-therapeutic approach to circumvent the immunotolerant state found in malignancies and chronic viral infections. Effector cells are supplied with designed specificities allowing redirection, and can be further equipped with co-stimulatory signals, together reverting the immunocompromised situation. To achieve retargeting against HBV-infected cells, we constructed tetravalent bispecific antibody constructs harboring two different binding domains of immunoglobulins. The first binding site was designed to target HBV-infected cells by binding the S domain of HBV env…
Schlagworte
Binding Sites
Dimerization
Cytokine
Hepatitis
Tumor
Zeitschrift für Gastroenterologie
