Impact of genetic polymorphisms in the SCARB1 gene on hepatitis C virus
M Deest, S Westhaus, F Stanke, MP Manns, T Berg, C Sarrazin, S Ciesek, T von Hahn · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: The scavenger receptor type B class I (SR-BI) is the physiological receptor for high density lipoproteins (HDL) on hepatocytes and the primary specific attachment receptor for hepatitis C virus (HCV). Numerous single-nucleotide polymorphisms (SNPs) have been described in the SCARB1 gene encoding SR-BI. Some of these are known to have a phenotype in the form of altered serum lipids, but their impact on HCV infection is unknown. Methods: We aimed to investigate SCARB1 SNPs with a high likelihood to affect HCV biology. All known SNPs that result in an amino acid exchange in the SR-BI protein (5 SNPs) we…
