The differential phenotype and functionality of CMV- and EBV-specific CD8 T cells in patients with chronic hepatitis C is associated with an altered plasma cytokine milieu
SS Owusu, PS Venkata, J Hengst, C Falk, S Hardtke, MP Manns, M Cornberg, H Wedemeyer, V Schlaphoff · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Persistent infections such as chronic hepatitis C (CHC) are often characterized by an ongoing inflammation and thus altered cytokine milieu due to the constant antigen stimulation. It is still under debate whether such persistent infections may also affect immune responses towards other pathogens. We therefore investigated the phenotype and function of CD8 T cells specific for common pathogens like CMV and EBV using PBMC from HLA-A2+ CHC patients (n= 37) and healthy blood donors (n= 31). Total and CMV/EBV-specific CD8 T cells were assessed for expression of PD-1, Tim-3 and 2B4 ex vivo and after in vitro stimulat…
