SEC14-like 3 is decreased in airway ciliated cells in experimental and paediatric asthma
S Bartel, N Schulz, AC Schamberger, F Alessandrini, P Pagel, FJ Theis, K Milger, E Noessner, SM Stick, A Kicic, O Eickelberg, RJ Freishtat, S Krauss-Etschmann · Pneumologie · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
*, **Equal contribution Background: Asthma is the most common chronic disease in children leading to respiratory dysfunction in adults if not identified correctly. Therefore, there is an unmet clinical need to find novel treatment targets for asthma pathogenesis. Objective: miRNA profiles were used to identify dysregulated signalling pathways in asthma as they are critical regulators of key molecules. Methods: Whole lung microRNAs were identified in mice with ovalbumin (OVA)-induced allergic inflammation by qualitative and quantitative microarrays. Target mRNAs, identified by in silico analysis were validated us…
