Changes of angiogenesis factors around delivery in preeclampsia and high risk patients

Background: The soluble fms-like tyrosine kinase (sFlt-1)/placental growth factor (PlGF) ratio seems to predict early-onset-preeclampsia (PE) and severe PE accurately. We tested if changes of sFlt-1, PIGF and sFlt-1/PIGF ratio directly before and after delivery are able to identify women at risk of complicated puerperal course in women delivering above 34 weeks of gestation. Methods: We investigated 22 singleton pregnancies with women at risk of PE (36.4% with gestational diabetes, 8.3% chronic hypertension, 13.6% gestational hypertension), but normal pregnancy outcome and 11 with PE. SFlt-1 and PlGF were measur…