Regulation of CD163 expression in human macrophages in diabetic conditions

Scavenging function of monocytes and macrophages is essential for the control of inflammatory reactions. The monocyte- and macrophage-specific scavenger receptor CD163 internalizes and degrades haemoglobin-haptoglobin complexes built due to intravascular haemolysis. This circumstance particularly occurs in inflammation, supporting the development of microvascular diabetic complications. The shedding of CD163 from the cell surface in inflammation leads to an impaired scavenging function and consequently increases the risk of vascular oxidative damage. The project aims to examine how high glucose conditions affect…