The role of BMP2 in the pathophysiology of obesity
M Unthan, E Guiu-Jurado, K Ruschke, D Schleinitz, M Kern, B Gutsmann, N Klöting, A Tönjes, M Stumvoll, P Kovacs, M Blüher · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Aims: Besides its known functions in the embryonic development the Bone Morphogenetic Protein 2 (BMP2) may affect adipogenesis and pancreatic β cell development. Our aim was to investigate the potential role of BMP2 in the pathophysiology of obesity and related traits. Subjects and methods: Circulating BMP2 levels were measured by ELISA (Cloud-Clone Corp.(USCN)) in a subset of serum samples from subjects derived from two phenotypically well characterized cohorts: the Sorbs (n = 638) and the Leipzig cohort (n = 489). Furthermore, we measured BMP2 mRNA expression by qRT-PCR in 632 paired samples of human subcutane…
