The effect of intraumbilical fetal nutrition via subcutaneously implanted port system on amino acid concentration by severe IUGR human fetuses

Objective: To determine if intrauterine intraumbilical supplementation with amino acids (AA) and glucose can improve neonatal outcome of severe growth restricted human fetuses (IUGR). Methods: Prospective pilot study of intrauterine treatment of severe IUGR fetuses (26.6 ± 3.3 week of gestation) with cerebroplacental ratio < 1 with long-term intraumbilical AA and glucose supplementation (10% of feto-placental blood volume/day) using perinatal port system (n = 6) and hyperbaric oxygenation (HBO). Results: Daily intravascular fetal nutrition prolonged the brain sparing to delivery interval by 23.3 ± 6.7 days vs. 5…