Green tea catechin epigallocatechin gallate causes apoptosis and shows potential synergism with cisplatin in biliary tract cancer cells

Question: Chemoresistance is a major problem that contributes to the high mortality rates of biliary tract cancer (BTC). It is known that the green tea catechin epigallocatechin gallate (EGCG) has anti-cancer effects alone or in combination with standard chemotherapeutics in various types of cancer, including BTC. In this study we investigated the cytotoxic effects of EGCG in BTC cells. We further investigated potential synergistic effects of EGCG and cisplatin chemotherapy. Methods: Cytotoxic effects of the drugs were evaluated in eight BTC cell lines using resazurin cell viability and caspase activity assays a…