Constitutive Fgf10 deficiency leads to impaired embryonic lung development

Objective: Fgf10 is known to be essential for lung development and regeneration. Our previous data showed that reduced Fgf10 expression leads to delayed embryonic lung development. The aim of this project is to investigate the role of constitutive Fgf10 deficiency in normoxic and hyperoxic condition (BPD mouse model). Methods: Transgenic mouse line of constitutive Fgf10 deficiency (Fgf10+/-, Fgf10 LacZ/-): In WT vs. Fgf10+/- and WT vs. Fgf10 LacZ/- gene expression analyses (whole lung) at E12.5, E18.5 and PN70 were done by using qRT – PCR (real-time PCR). BPD mouse model: WT vs. Fgf10+/- mice were exposed to 85%…