The influence of EGF/HGF receptor abundance on therapy resistance in NSCLC cell lines

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. Unfortunately, the currently available systemic therapies including chemotherapy and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment lead to only a few months increased survival due to resistance formation. It is suspected that both resistances can be mediated by EGF and hepatocyte growth factor (HGF) interaction. Yet, the mechanism of this EGF/HGF mediated resistance remains unknown. In this study time resolved quantitative data for EGF and HGF induced signal transduction was acquired in…