Pressurized intraperitoneal aerosol chemotherapy (PIPAC) with cisplatin and doxorubicin in 99 women with gynecologic malignancies and peritoneal carcinomatosis: a retrospective co…
C Tempfer, G Rezniczek, M Tsitas, P Ende, W Solass, C Demtroeder, MA Reymond · Geburtshilfe und Frauenheilkunde · 2015 · Heft 08
Bibliografische Angaben
Zusammenfassung
Objective: To assess the objective tumor response (OTR) of laparoscopic pressurized intraperitoneal aerosol chemotherapy (PIPAC) in women with gynecologic malignancies and peritoneal carcinomatosis (PC). Methods: Retrospective cohort study using registry data of women with repeated courses q 28 – 42 days of PIPAC with cisplatin 7.5 mg/m2 and doxorubicin 1.5 mg/m2. OTR was defined as histological regression. Peritoneal carcinomatosis index (PCI) improvement on video-laparoscopy and ascites volume reduction were secondary outcomes. Quality of life was assessed using the EORTC QLQ-30(+3) questionnaire. Results: 252…