Procholestatic gene variants and mutations in secondary sclerosing cholangitis in critically ill patients (SC-CIP)

Background and Aim: Secondary sclerosing cholangitis in critically ill patients (SC-CIP) has been recently defined as new disease entity. Its pathogenesis is unclear but ischemia and "toxic bile" might be involved in the development of SC-CIP. It was our aim now to study selected procholestatic gene variants and mutations in patients who developed SSC after an ICU stay. Methods: In total, we screened data of 4,641 cholangiography procedures performed between January 2008 and April 2015 at Saarland University Medical Center. In total, we identified 17 patients (age 33 – 80 years, 14 males) with a history of ICU t…