Nuclear ErbB2 Expression of Hepatocytes in Alcoholic Steatohepatitis as Response to Cellular Stress Events

Background: ErbB2 is a prominent member of the epidermal growth factor receptor superfamily, a group of transmembrane receptors that mainly attract attention as oncogenic drivers and therapeutic targets in cancer. Besides transmembrane signaling, ErbB2 may also translocate into the nucleus and mediate distinct nuclear signaling effects, including DNA repair and cell cycle arrest. Methods: The immunohistochemical pattern of ErbB2 staining was analyzed in 334 liver biopsy samples from patients with hepatic dysfunction. Results: We found a cytoplasmic and nuclear ErbB2 expression in hepatocytes from different disea…