miR-1224 is upregulated in hepatic ischemia-reperfusion injury and induces cell death via Sp1 inhibition

Background: MicroRNAs (miRNAs) are small non-coding RNAs that modulate the activity of gene expression. Only few data describe the role and expression of miRNAs in liver ischemia-reperfusion (IR) injury. IR is a major cause of liver damage during surgical procedures including liver transplantation. Therefore, in this study we sought to identify the potential involvement of miRNAs in IR injury in mice. Method: PCR-based miRNA microarray was performed with the liver samples of mice subjected to IR injury and sham. The effect of miR-1224 was assessed by serum enzyme analysis and histological examination of liver. T…