Redundant tolerance mechanisms prevent autoimmune liver inflammation in mice
L Leypoldt, A Laschtowitz, C Schramm, S Huber, AW Lohse, A Carambia, J Herkel · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Background: The role of Foxp3+ regulatory T cells (Tregs) in autoimmune liver inflammation is still being discussed. Whereas some reports suggested that autoimmune liver inflammation is linked to Treg dysfunction, others could not confirm this observation. Aims: Here, we investigated the consequences of Treg or IL-10 impairment for the development of autoimmune hepatitis. We used a mouse model that is characterised both by ectopic expression of the prototypical autoantigen myelin basic protein (MBP) in the liver and by the presence of autoreactive MBP-specific T cells due to a transgenic T cell receptor. Methods…
