Airway epithelial cells secrete altered exosomal microRNAs in murine experimental and human paediatric asthma
S Bartel, N Schulz, A Schamberger, F Alessandrini, E Noessner, SM Stick, A Kicic, O Eickelberg, RJ Freishtat, S Krauss-Etschmann · Pneumologie · 2016 · Heft 02
Bibliografische Angaben
Zusammenfassung
Background: miRNAs (miR) are critical regulators of the immune system. Recently they have been shown to be secreted into exosomes for inter-cell communication (Valadi et al., Nat Cell Biol, 2007). We previously identified an up-regulation of miR-17, -144 and -21 in murine lung homogenate in Ovalbumin (OVA) induced allergic airway inflammation (AAI) and in nasal epithelial cells of children with allergic asthma. Objective: We now aimed to decipher the role of the bronchial epithelium in the production and secretion of miRNAs in asthma. Methods: Primary normal human bronchial epithelial (NHBE) cells were cultured…
