MR-perfusion derived hemodynamic parametric response mapping of bevacizumab efficacy in recurrent glioblastoma
P Kickingereder, P Kickingereder, A Radbruch, S Burth, A Wick, S Heiland, H Schlemmer, W Wick, M Bendszus, D Bonekamp · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2016 · Heft 03
Bibliografische Angaben
Zusammenfassung
Zielsetzung: Bevacizumab has proven beneficial in patients with recurrent glioblastoma (rGB), however its impact on tumor blood flow and oxygenation status remains controversial. Here we examine dynamic susceptibility-weighted contrast-enhanced MRI (DSC-MRI) derived Gaussian-normalized, relative cerebral blood volume and flow (nrCBV, nrCBF) parametric-response-maps (PRMs), for predicting response to bevacizumab in patients with rGB. Material und Methodik: A total of 71 patients diagnosed with rGB underwent conventional-anatomic MRI and DSC-MRI at baseline and at first follow-up after bevacizumab initiation. PRMs…