Sildenafil potentiates the cytostatic effect of doxorubicin in pediatric epithelial liver tumors

Introduction: The hepatoblastoma (HB) and pediatric hepatocellular carcinoma (pHCC) are the most common liver tumors in infancy and childhood. Treatment results have been improved particularly for the HB over the last two decades by establishing treatment regimes that combine neoadjuvant and adjuvant chemotherapy with surgery. However survival in advanced diseases is still poor. Therapeutic results for children with HCC are generally poor despite a general increase in survival rates for most solid tumours among this age group. In the present study, we want to investigate whether established phosphodiesterase 5 (…