Antiinflammatory properties of PAH drugs

In patients suffering from pulmonary arterial hypertension (PAH) elevated levels of monocyte-derived cytokines have been described in early stage of disease. Beside vasodilatory potential, specific anti-inflammatory activities of current PAH drugs might contribute to their therapeutic efficacy. We studied the anti-inflammatory properties of different classes of PAH drugs in human cultured monocytes. CD14+ monocytes were isolated from blood taken from healthy donors with their informed consent. Peripheral mononuclear cells were isolated via density gradient centrifugation, following by magnetic cells sorting with…