Transferrin Saturation Defines Distinct Subtypes of Dysmetabolic Iron Overload Syndrome

A significant proportion of patients with hepatic iron overload tests negative for hemochromatosis-associated genotypes. Due to the high prevalence of metabolic syndrome among these patients, this condition is referred to as dysmetabolic iron overload syndrome (DIOS). In contrast to HFE associated hemochromatosis, which is typically associated with high transferrin saturation, transferrin saturation is variable in DIOS. The aim of the present study was to delineate if DIOS patients with high transferrin saturation are a distinct subgroup. Among 193 patients who underwent non-invasive liver iron quantification fo…