Impact of bile acids on immunometabolic parameters after LAGB
V Thöni, A Pfister, A Melmer, B Enrich, K Salzmann, C Ebenbichler, H Tilg, A Moschen · Zeitschrift für Gastroenterologie · 2016 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background & Aims: Bariatric surgery is an effective treatment for severe obesity and its associated conditions such as type-2 diabetes and NAFLD/NASH. A postoperative rise of bile acids (BA) and activation of hepatic FXR have been suggested pivotal drivers of the metabolic improvements. The aim of this study was to assess alterations in hepatic FXR expression and systemic BA profiles before and after weight loss and their relation to metabolism and inflammation. Methods: We investigated the effect of weight loss on BA profiles, which were determined by mass spectroscopy in serum samples of 20 patients before, 3…
