NanoCOLT-Modulatory effects of modified carbon black nanoparticles in a mouse model of allergic asthma

Rationale: Nanoparticles in form of industrial carbon black nanoparticles (CBNP) are the most commonly produced nanoparticles worldwide. CBNP can get into the lung via inhalation and may present a potential health risk. Recent studies showed that exposure of nanoparticles can trigger acute asthma exacerbation that lead to enhanced inflammation and mucus production. However, until yet, it is unknown, whether the risk potential arises directly or indirectly from the surface of the CBNP. Thus, the aim of this study was to investigate the modulatory effects of different modified and well-characterized CBNP in a mous…