Cytoprotective and anti-inflammatory effects of STW 3-VI (Hypericum perforatum extract) in vitro

Inflammation and glutamate toxicity play an integral role in a variety of disorders as depression. Additionally, a large body of evidence indicates that adaptation to chronic stress involves response from both, the neuroendocrine and immune systems. Depression also has been linked to an inflammatory response since pro-inflammatory cytokines like interleukin 6 (IL-6) and tumor necrosis factor (TNFα) are increased in depressed patients. In this context, the combined antioxidant and anti-inflammatory properties of Hypericum perforatum (St. John's wort) extract is suggested to contribute to the antidepressant effect…