Erythropoietin exhibit angiogenic potential and the role of erythropoietin receptor in lung cancer cells

Background: Recombinant human erythropoietins (rHuEPOs), a hormone regulating proliferation and differentiation of erythroid cells is one of the prescription drugs to treat cancer associate anemia. However, rHuEPOs administration to lung cancer patients has been reported to associate with decreased survival, and the mechanism remains controversial. Objectives: To investigation the angiogenic effect of EPO on human vascular endothelial cells in an in vitro 3D cell culture model. The expression of EPO-Receptor in lung cancer cells including EGFR (epidermal growth factor receptor) wild type/EGFR gene mutation cell…