Sevoflurane preconditioning attenuates lung injury after mouse lung transplantation
Y Yamada, I Laube, JH Jang, T Maeyashiki, J Bonvini, I Inci, B Beck Schimmer, W Weder, W Jungraithmayr · Zentralblatt für Chirurgie · 2016 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background: Although sevoflurane has been shown to ameliorate ischemic reperfusion injury in various organs, data available seem inconsistent particularly for the lung. We therefore evaluated if preconditioning by sevoflurane could potentially protects from primary graft dysfunction (PGD) and acute rejection (AR) after lung transplantation (Tx). Methods: Three experimental approaches were employed; [1] C57BL/6 mice were preconditioned for 2 hours with sevoflurane (Sevo) or fentanyl (Control) and analyzed (n = 10), [2] syngeneic mouse lung Tx (C57BL/6) with a preconditioned graft followed by 18 hours of cold stor…
