Fetal loss following invasive prenatal testing: a comparison of transadominal chorionic villus sampling, transcervical chorionic villus sampling and amniocentesis

Purpose: The aim of this study was to compare transabdominal chorionic villus sampling, transcervical chorionic villus sampling and amniocentesis with respect to their total fetal loss rates. Material and methods: We retrospectively evaluated procedures of invasive prenatal testing performed during a 14-year period (2001 – 2014) including 936 amniocentesis procedures and 1051 chorionic villus samplings, of which 405 cases were executed transabdominally and 646 transcervically. Only singleton pregnancies before 24+0 weeks of gestation where the pregnancy outcome was known were included. Fetal loss was defined as…