Response of severe IUGR human fetuses with brain sparing to amino acids supplementation via subcutaneously implanted port system with and without hyperbaric oxygenation

Objective: This study aims to treat severe placental insufficiency with amino acid and glucose intraumbilical supplementation via a port system and hyperbaric oxygenation (HBO). Study design: A prospective clinical study of 6 IUGR very preterm human fetuses with cerebroplacental ratio < 1 with long-term intraumbilical amino acid and glucose supplementation, using subcutaneously implanted port system (10% of feto-placental blood volume/day, n = 6) and HBO (1.4 Bar, n = 1). Results: Fetal nutrition significantly reduced the pulsatility index in the umbilical artery after first week from 2.44 ± 1.35 to 1.47 ± 0.53…