Experiences with off-lable use of bevacizumab in patients with first-diagnosed locally advanced and metastatic cervical cancer

Introduction: Invasive cervical cancer is the fourth most cancer of women in western civilization. Complete recurrence rates after neoadjuvant therapy in bulky disease remain poor and new strategies are needed. Here, we present our clinical experiences with platinum- and taxane based cytotoxic therapy in combination with bevacizumab in patients with cervical cancer. Methods: All patients from 2008 – 2015 with locally advanced and metastatic cervical cancer who have been treated with radiochemotherapy or platinumbased chemotherapy in combination with or without bevacizumab were included in this retrospective stud…