The function of B-cell lymphoma 6 in trophoblastic cells

Aim: Preeclampsia is one of the leading causes of maternal and perinatal mortality and morbidity and although its pathogenesis is not fully understood. B-cell lymphoma 6 (BCL6), a key regulator of B-lymphocyte development, is altered in preeclamptic placentas suggestive of its involvement in trophoblast function in the early stage of placental development. Materials & Methods: Molecular biological methods were used to study the function of BCL6 in trophoblastic cell lines and primary trophoblasts. Results: We show that BCL6 is present in three trophoblast cell lines and it is predominantly expressed in trophobla…