Clinical performance of GynTect – DNA methylation markers for triaging HPV-positive women

Objectives: High-risk human papillomavirus (hrHPV)-DNA testing is frequently performed after abnormal cytology results for the detection of high-grade dysplasia and cervical cancer (CIN3+), particularly in women above 30 years of age. Although highly sensitive, hrHPV testing has only limited specificity. Therefore, triaging of women tested HPV-positive is of high relevance, even in case of underlying abnormal cytology. Methods: In a retrospective, cross-sectional study with two gynecological hospitals residual material from cervical scrapes from more than 300 patients with histopathology-confirmed diagnosis were…