High-grade serous ovarian and peritoneal cancers display distinct genetic and post-translational signatures – a criterion to treat them differently?
F Jacob, M Anugraham, A Schötzau, A Everest-Dass, N Bovin, M Huflejt, A Fedier, N Hacker, D Fink, N Packer, V Heinzelmann-Schwarz · Geburtshilfe und Frauenheilkunde · 2016 · Heft 10
Bibliografische Angaben
Zusammenfassung
Introduction and aim: High-grade serous ovarian (HGSOC), tubal, and peritoneal adenocarcinomas (HGSPC), commonly presenting at an advanced stage and being associated with high mortality rates, are currently treated the same way. We hypothesize that HGSOC and HGSPC are distinguishable by their genetic and molecular profiles and hence are different diseases. Material and methods: Two independent cohorts (560 patients) were reviewed regarding relapse- and disease-free survival in HGSOC and HGSPC; differential gene expression was determined by Tothill data analysis; differential glycoprotein and post-translational g…
