Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA
C Klein, CT Bock, H Wedemeyer, T Wüstefeld, S Locarnini, HP Dienes, MP Manns, C Trautwein · Zeitschrift für Gastroenterologie · 2015 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background / Aim: Hepatitis B Virus (HBV) causes acute and chronic infections which may result in severe liver diseases. Animal models to study new treatment options in vivo have several drawbacks. Therefore we were interested to establish a new small animal model where HBV replication and especially new treatment options can be studied easily. Methods: Naked DNA of a HBV-replication competent vector was transferred via tail vein into NMRI mice. HBV replication was studied in serum and liver of the animals. HBV replication was modulated by treatment through siRNA and nucleoside analogues. Results: Tail vein tran…
