Is chronic recurrent multifocal osteomyelitis a part of chronic non-bacterial osteomyelitis in children?

Chronic recurrent multifocal osteomyelitis (CRMO) in children per definition describes a chronic nonbacterial inflammatory process of bone at multiple sites, of recurrent nature. Clinically, however, a significant number of children affected by chronic non-bacterial osteomyelitis (CNBO) do not experience a recurrent course, especially under anti-inflammatory treatment. In addition, there are patients who suffer from a single lesion with or without a recurrent course of disease. Of 30 CNBO patients (mean follow up 5 years), 9 had a unifocal lesion with no relapse, 3 a unifocal lesion with relapses, 9 multifocal l…