Seizures immediately following intravenous pulse methylprednisolone in a 12-year-old girl with systemic lupus erythematodes

Neurological complications of systemic lupus erythematodes (SLE) are less well known in pediatric compared to adult patients. Case report: A currently 12-year-old girl presented with abdominal pain and facial rash over a period of two weeks. Previously, no neurological or psychiatric symptoms have been observed. SLE was diagnosed and treatment was immediately initiated with a first intravenous pulse of methylprednisolone (500mg per day for 3 days followed by oral prednisolone). Three days after the first dose the patient experienced a prolonged complex focal seizure that lead to severe respiratory insufficiency…