CareLit Fachartikel

Interaction of nitric oxide and prostanoids in Kupffer cells during inflammation

Y Bezugla, A Kolada, S Kamionka, B Bernard, R Scheibe, P Dieter · Zeitschrift für Gastroenterologie · 2004 · Heft 02

Dokument
1038483
CareLit-ID
Jahr
2004
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
Y Bezugla, A Kolada, S Kamionka, B Bernard, R Scheibe, P Dieter
Ausgabe
Heft 02 / 2004
Seiten
–
Erschienen: 2004-02-02 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2004-816045

Zusammenfassung

Resident liver macrophages (Kupffer cells) are the main producers of nitric oxide (NO) and prostanoids (prostaglandin (PG) E2 and thromboxane (Tx) B2) among non-parenchymal cells during liver damage. Inflammatory agents (lipopolysaccharides (LPS), cytokines (tumour necrosis factor (TNF) α and interleukine (IL)-1β) activate Kupffer cells to release enhanced amounts of NO, PGE2 and TxB2, which, in their turn, are important for modulation of hepatocyte’s response to liver inflammation. The aim of this study was to explore the relationship between NO and prostanoids production in rat Kupffer cells during inflammatio…

Schlagworte

Kupffer cells Nonparenchymal cells cytokine interleukene nitric oxide prostaglandin prostanoid thromboxane Zeitschrift für Gastroenterologie