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The Export Pump MRP4 (ABCC4) is Localized to the Basolateral Membrane of Hepatocytes and Mediates Cotransport of Reduced Glutathione with Bile Salts

M Rius, AT Nies, J Hummel-Eisenbeiss, G Jedlitschky, D Keppler · Zeitschrift für Gastroenterologie · 2004 · Heft 02

Dokument
1038488
CareLit-ID
Jahr
2004
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
M Rius, AT Nies, J Hummel-Eisenbeiss, G Jedlitschky, D Keppler
Ausgabe
Heft 02 / 2004
Seiten
–
Erschienen: 2004-02-02 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2004-816095

Zusammenfassung

The liver is the major source of reduced glutathione which is released predominantly across the basolateral (sinusoidal) membrane into the blood circulation and serves as the principal source of plasma GSH, cysteine, and cystine. The transport protein mediating the efflux of GSH across the basolateral membrane of human hepatocytes has not been identified so far. We have localized the multidrug resistance protein 4 (MRP4; ABCC4) to the basolateral membrane of human, rat, and mouse hepatocytes, and human hepatoma HepG2 cells. Recombinant human MRP4, expressed in V79 hamster fibroblasts and studied in membrane vesi…

Schlagworte

ABCC4 GSH bile salts cholyltaurine hepatocyte membrane transport multidrug resistance protein 4 Zeitschrift für Gastroenterologie