Influence of promoter polymorphism in the CD14 gene on the course of Crohn's disease

Background: CD14 (LPS receptor) interacts with luminal bacterial constituents and plays a signal role in the release of cytokines. A functionally relevant C(-159)T polymorphism in the promoter region of CD14 is associated with several diseases, but the role of this polymorphism in CD is controversial. The aim of our study was to investigate the frequency of C/T CD14 polymorphism in CD with different types of severity in comparison with ethnically matched healthy controls. Material and methods: Blood samples from 143 CD patients and 75 blood donors were collected; all clinical data on the patients were registered…