SOX18 is a target gene of the Shh-Ptc pathway in murine cerebellar granule cell precursors and is highly expressed in human desmoplastic medulloblastomas
H Brune, R Buslei, A Koch, W Hartmann, U Schüller, J Kraetzschmar, OD Wiestler, K Schilling, T Pietsch · Klinische Pädiatrie · 2004 · Heft 05
Bibliografische Angaben
Zusammenfassung
Medulloblastomas (MBs) are the most frequent malignant brain tumours in childhood and can be subdivided into the classic and the desmoplastic variant. The latter arises from cerebellar granule cell progenitors (GCPs) of the external granule cell layer (EGL). Its pathogenesis is linked to an overactivation of the Sonic Hedgehog-Patched (Shh-Ptc) pathway. By culturing murine GCPs in the presence or absence of the morphogen Shh, respectively, we identified the gene for the transcription factor Sox18 to be highly induced by Shh using DNA microarray and subsequent competitive RT-PCR. In situ hybridization showed that…
