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Transcriptional Regulation of the lymphangiogenic factor VEGF-D: critical role of orphan receptors and promoter acetylation

C Wißmann, AM Beyer, G Schäfer, F Gao, V Lunyak, M Höcker · Zeitschrift für Gastroenterologie · 2004 · Heft 08

Dokument
1039083
CareLit-ID
Jahr
2004
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
C Wißmann, AM Beyer, G Schäfer, F Gao, V Lunyak, M Höcker
Ausgabe
Heft 08 / 2004
Seiten
–
Erschienen: 2004-08-18 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2004-831665

Zusammenfassung

Aims: Vascular endothelial growth factor D (VEGF-D) is a ligand for VEGF receptor 3 (VEGFR–3/flt4) and has been implicated in lymphatic development and metastases. VEGF-D expression correlates with lymphatic tumor spread and poor disease outcome; our own studies identified VEGF-D as novel independent prognostic marker in gastric cancer. Despite this clinical importance, the molecular mechanisms controlling VEGF-D are largely unknown. Aim: Detailed characterization of the mechanisms controlling VEGF-D transcription as a basis for development of new intervention strategies influencing lymphangiogenesis and lymphat…

Schlagworte

Vascular endothelial growth factor D acetylation direct repeat element lymphatic differentiation lymphatic metastases orphan receptors Chromatin Immunoprecipitation Chromatin After Tumor Zeitschrift für Gastroenterologie