Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, do…
A Sutter, K Maaser, P Grabowski, M Höpfner, A Krahn, B Heine, H Stein, R Somasundaram, D Schuppan, M Zeitz, H Scherübl · Zeitschrift für Gastroenterologie · 2004 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background/Aims: Hepatocellular carcinoma (HCC) is one of the most common causes of cancer deaths worldwide. Thus, novel therapies are urgently needed. A promising approach is the use of peripheral benzodiazepine receptor (PBR) ligands which have been shown to inhibit the proliferation of various tumors. There exist no functional studies of PBR in HCC Methods: PBR expression both in human HCC cell lines and in tumor specimens of HCC patients was analyzed by RT-PCR and immunostaining. To evaluate PBR as a target for the treatment of HCC, we tested the effects of PBR ligands on human HCC cells. Results: PBR was lo…
