Quantitative Analysis of Hepatic CCCDNA during Combination Therapy of Peginterferon ALFA 2B Plus Adefovir Dipivoxil in Patients with Chronic Hepatitis B: Interim Analysis of a sin…
K Wursthorn, P Buggisch, F Metzler, B Zöllner, M Zankel, C Fischer, S Xiong, C Gibbs, H Greten, J Petersen · Zeitschrift für Gastroenterologie · 2004 · Heft 08
Bibliografische Angaben
Zusammenfassung
Background: Hepatitis B Virus cccDNA is the replicative intermediate in the nuclei of infected hepatocytes that is responsible for viral persistence during chronic HBV infection and antiviral therapy. The aims of this study were 1) to determine changes in intrahepatic cccDNA levels in paired biopsy samples from patients during therapy with Peginterferon alfa 2b and adefovir dipivoxil (primary endpoint) using a quantitative PCR assay (Werle, Gastroenterology, in press) and 2) to study the safety and efficacy of the combination therapy for 48 weeks. Methods: 17 of 26 patients completed the 48 week course of combin…
