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Intrinsic Epileptogenicity in Polymicrogyria: Loss of Deep Cortical Fissures Requires Simultaneous EEG with MEG Source Analysis

T Bast, O Özkan, G Ramantani, T Metzke, A Seitz, R Andre, D Rating, M Scherg · Klinische Neurophysiologie · 2004 · Heft 08

Dokument
1039105
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Jahr
2004
Publikation
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Bibliografische Angaben

Zeitschrift
Klinische Neurophysiologie
Autor:innen
T Bast, O Özkan, G Ramantani, T Metzke, A Seitz, R Andre, D Rating, M Scherg
Ausgabe
Heft 08 / 2004
Seiten
–
Erschienen: 2004-08-25 00:00:00
ISSN
1434-0275
DOI
10.1055/s-2004-831925

Zusammenfassung

Purpose: Multiple source analysis of interictal EEG and MEG spikes was applied to the determination of potential epileptogenic zones in polymicrogyria (PMG). PMG is characterized by a marked loss of deep cortical fissures. Since MEG signals are predominantly generated from tangentially oriented neurons in fissures, an MEG/EEG discrepancy was assumed. Patients: We studied 7 patients (age 7.5 to 19 years) with localization-related epilepsy and unilateral polymicrogyria (PMG) as defined by anatomical MRI. Methods: 122-channel whole-head MEG and 32-channel EEG were recorded simultaneously for 25 to 40 minutes. Using…

Schlagworte

Spike Onset Activity Types Source Interictal Patients Localized Polymicrogyria Fissures Analysis Multiple Klinische Neurophysiologie